Sticchi et al reported 5 mutations, including p.Asn542Ser and p.Lys2460Arg of FBN1, p.Val1739Met of NOTCH1, p.Arg1330Gln of LTBP1, and p.Arg423Trp of TGFBR3 in an MFS patient with bicuspid aortic valve and aortic symptoms. Here, LTBP1 is linked to Marfan syndrome.