Pedroza et al found a cluster of modulated smooth muscle cells (SMCs) in aortic aneurysm tissue of an adult FBN1C1041G/+ mouse model by scRNA seq, and upregulated activity of TGF-β signaling, and expression of Kruppel-like factor 4 (Klf4) may be a potential upstream driver that promotes SMCs modulation 89. Here, KLF4 is linked to aortic aneurysm.