FBN1 and Marfan syndrome: Sticchi et al reported 5 mutations, including p.Asn542Ser and p.Lys2460Arg of FBN1, p.Val1739Met of NOTCH1, p.Arg1330Gln of LTBP1, and p.Arg423Trp of TGFBR3 in an MFS patient with bicuspid aortic valve and aortic symptoms.