Shorter survival of breast cancer patients with high expression of SLC4A7 mRNA (Figure 10D,G) is consistent with the greater tendency for lymph node metastasis among patients with high NBCn1 protein expression and accelerated Na+,HCO3– cotransport (Figure 8G) as well as with the enhanced proliferative activity in patients with elevated steady-state pHi due to Na+,HCO3– cotransport (Figure 7G). This evidence concerns the gene SLC4A7 and metastatic malignant neoplasm in the lymph nodes.