This increased influence of Na+,HCO3– cotransport in invasive lobular carcinomas was more pronounced with respect to steady-state pHi control where it reached statistical significance both before (Figure 2D) and after (Figure 6B) we adjusted for variation in other clinicopathological characteristics (i.e., patient age, tumor size, malignancy grade, estrogen receptor expression, and HER2 status). The gene discussed is ESR1; the disease is invasive lobular breast carcinoma.