CDH1 and cancer: Lost expression of the cell-cell adhesion molecule E-cadherin can explain the tendency for cancer cells from lobular carcinomas to invade in single file (Gamallo et al., 1993; Pai et al., 2013), which is more difficult to delineate by mammography, and thus account for the higher positive surgical margin rates following lumpectomy procedures (van Deurzen, 2016).