The chemokine CCL2, which can be produced by pancreatic cancer cells, facilitates the recruitment of immunosuppressive C–C motif chemokine receptor 2-positive TAMs into the tumor microenvironment, thereby limiting T cell infiltration.267,268 CXCL5 is an important attractant for immune cell accumulation. This evidence concerns the gene CXCL5 and familial pancreatic carcinoma.