FASN and familial pancreatic carcinoma: In mice, a high-fat diet can increase oncogenic KRAS activity, leading to fibrosis, inflammation, and enhanced PDAC development.191 It has been demonstrated that multiple enzymes that catalyze de novo fatty acid (FAs) synthesis, including ATP citrate lyase, FA synthase (FASN), and stearoyl-CoA desaturase, are obviously upregulated in pancreatic cancer.192,193 In addition, increased FASN expression was correlated with poor survival and poor gemcitabine responsiveness through enhanced estrogen receptor stress and cancer stemness.