SLC38A9 and pancreatic neoplasm: A recent study reported that Arg deprivation inhibits pancreatic cancer cell migration, invasion, and EMT.177 The mammalian target of rapamycin complex 1 (mTORC1) kinase is a master growth regulator that senses many environmental cues, including amino acid levels.178,179 Via solute carrier family 38 member 9, Arg serves as a lysosomal messenger that couples mTORC1 activation to the lysosomal release of essential amino acids needed to drive pancreatic cancer cell growth.179,180