FOXP3 and familial pancreatic carcinoma: TAMs can respond to environmental signals (e.g., inflammatory cytokines IL-8, IL-6, IL-1β, IL-10),222 and it is thought that a high number of infiltrating TAMs may correlate with tumor size, prognosis, and patient survival in pancreatic cancer.223 Forkhead box P3-positive (Foxp3+) Tregs are a subtype of T cells with significant roles in immunological self-tolerance maintenance and immunosuppression modulation during tumor progression.