Efforts have also been made to simplify the classification of pancreatic cancer samples using surrogate markers, e.g., TP63,335YAP1,92HNF1 homeobox A, keratin 81 (KRT81),50GATA6,44,46 and KRT17.336 Interestingly, Kaissis et al. reported that a machine learning-based analysis of preoperative CT images could predict molecular pancreatic cancer subtypes.337 These findings might facilitate clinical patient stratification and provide guidance for precision medicine. This evidence concerns the gene KRT81 and familial pancreatic carcinoma.