KLF4 and pancreatic neoplasm: A number of ncRNAs,117,118 transcription factors (e.g., Kruppel-like factor 4 (KLF4),119 KLF5,120 KLF7121), growth factors (e.g., vascular endothelial growth factor (VEGF)122), and oxygen conditions123 have been reported to drive pancreatic cancer metastasis.