CD8A and familial pancreatic carcinoma: Foxp3+ Tregs have been shown to interact with tumor-associated CD11c+ dendritic cells and to restrain the immunogenic activation of CD8+ T cells.224 In pancreatic cancer, Foxp3+ Tregs are an essential source of TGF-β ligands, promoting the differentiation of SMA+ fibroblasts (myCAF) for tumor progression.