A number of ncRNAs,117,118 transcription factors (e.g., Kruppel-like factor 4 (KLF4),119 KLF5,120 KLF7121), growth factors (e.g., vascular endothelial growth factor (VEGF)122), and oxygen conditions123 have been reported to drive pancreatic cancer metastasis. This evidence concerns the gene KLF4 and familial pancreatic carcinoma.