KRAS and familial pancreatic carcinoma: In an oncogenic KRAS mouse model, the comparative transcriptomic analysis identified lipid-related metabolic pathways, in particular cholesterol uptake, as being the most highly enriched in pancreatic cancer (compared with a normal pancreas).192 Pancreatic cancer patients with increased expression of cholesterol synthesis genes showed a survival benefit in resectable and metastatic cases.154 Furthermore, cholesterol metabolism plays an important role in controlling pancreatic cancer development and differentiation.