RELA and lung cancer: Previous study identified that CXCL8 expression is regulated via activation of the NF-κB signaling pathway in lung cancer.26 To elucidate the interaction of NF-κB/p65 and CXCL8, we searched to approximately 2000 base pairs (bps) of the promoter regions of CXCL8 genes for putative NF-κB/p65 binding sites and constructed the promoter reporters including the predicted binding sites through UCSC genome browser (http://genome.ucsc.edu/) and JASPAR database (http://jaspardev.genereg.net) (Fig. 5a).