To identify the pro-carcinogenic role of KTN1 in vivo, we assessed the effects of KTN1 overexpression, and CXCL8 knockdown by siRNA oligos of cholesterol and dimethoxy-modified in KTN1 overexpressed cells on MDA-MB-231 xenograft mammary tumor growth in NOD/SCID/IL2rγ null (NSG) mice. Here, CXCL8 is linked to breast cancer.