CCDC80 [139], CMA1 [140], MDK (midkine) [141], GNA14 [142], SCG2 [143], NPPB (natriuretic peptide B) [144], FGF10 [145], ARNTL (aryl hydrocarbon receptor nuclear translocator like) [146], WNK3 [147], EDNRB (endothelin receptor type B) [148], THBS1 [149], SELE (selectin E) [150], SLC4A7 [151], AQP4 [152] and KCNK3 [153] are thought to be responsible for progression of hypertension, but these genes might to be associated with progression of HF. The gene discussed is EDNRB; the disease is hypertensive disorder.