FSCN1, TMEM30B, CENPA (centromere protein A), CEP55, HBB (hemoglobin subunit beta), ANLN (anillin actin binding protein), hsa-mir-4533, hsa-mir-548ac, hsa-mir-548i, hsa-mir-5585-3p, hsa-mir-6750-3p, hsa-mir-200c-3p, hsa-mir-1244, RERE(arginine-glutamic acid dipeptide repeats), HMG20B, MXD3, ARID4B, CBFB (core-binding factor subunit beta), TAF7 and CREM (cAMP response element modulator) might be the novel biomarker for HF. The gene discussed is CBFB; the disease is hydrops fetalis.