Cai et al. [123], Mo et al. [124], Sun et al. [125], Martinelli et al. [126], Zhao et al. [127], Assimes et al. [128] and Piechota et al. [129] showed that CCR7, FCN1, ESM1, F8 (coagulation factor VIII), C1QTNF1, ALOX5 and MSR1 were an important target gene for coronary artery disease. This evidence concerns the gene F8 and coronary artery disorder.