Genes such as COMP (cartilage oligomeric matrix protein) [131], CHI3L1 [132], PLA2G2A [133], P2RY12 [134], CR1 [135], HPSE (heparanase) [136], PTX3 [137] and SERPINE1 [138] were related to atherosclerosis. The gene discussed is HPSE; the disease is atherosclerosis.