CNTNAP2 [154], GLI2 [155], DPT (dermatopontin) [156], AEBP1 [157], ITIH5 [158], CXCL11 [159], GDNF (glial cell derived neurotrophic factor) [160], MCHR1 [161], FLT3 [162], ELANE (elastase, neutrophil expressed) [163], OSMR (oncostatin M receptor) [164] and IL15RA [165] are involved in development of obesity, but these genes might be key for progression of HF. The gene discussed is ELANE; the disease is obesity due to melanocortin 4 receptor deficiency.