The results suggested that the mRNA expression level of ESR1, PYHIN1, PPP2R2B, LCK and TP63 were significantly increased in HF compared with that in normal, while PCLAF, CFTR, TK1, ECT2 and FKBP5 were significantly decreased in HF compared with that in normal and are shown in Fig. 7. The gene discussed is PYHIN1; the disease is hydrops fetalis.