The X- RAY crystallographic structure of one proteins from each over expressed genes of ESR1, LCK, PPP2R2B, PYHIN1, TP63 and their co-crystallised protein of PDB code 4PXM, 1KSW, 2HV7, 3VD8 and 6RU6 respectively were selected for the docking studies to identify and predict the potential molecule based on the binding score with the protein and successful in heart failure. Here, PYHIN1 is linked to heart failure.