In addition, the volcano map revealed that the expression levels of CCL5, CXCR6, CD3E and LCK were up-regulated in tumor tissues, and CTLA4 expression was down-regulated in tumor tissues compared with in normal tissues (Fig. 7j) based on screening criteria of P < 0.05 and |log2FC| > 1. The gene discussed is LCK; the disease is neoplasm.