TP53 and B-cell chronic lymphocytic leukemia: 临床特征:329例CLL患者男女比例2∶1,中位年龄59岁。85例(25.8%)有B症状,24.3%有贫血,31.0%有血小板减少,18.2%有白蛋白减少,21.6%有LDH增高,45.0%有β2-微球蛋白(β2-MG)水平增高。69.0%为Binet B或C期,23.6%有TP53异常,38.3% IGHV无突变,14.0%存在del(11q),24.0%为CD38表达阳性。