Accordingly, after treatment with the Akt phosphorylation selective inhibitor MK‐2206 and the NF‐κB nuclear translocation inhibitor JSH‐23, LAMC1‐overexpressing ESCC cells showed the opposite results in proliferation and expression of cleaved caspase and PARP (Fig. 4D). This evidence concerns the gene LAMC1 and esophageal squamous cell carcinoma.