We confirmed that TGFβ1 acted on tumor cells, causing a series of changes: upregulation of LAMC1; phosphorylation of NF‐κB; secretion of CXCL1; phosphorylation of STAT3 in CAF; and finally, the induction of the formation of iCAF, that is, tumor‐promoting CAF. This evidence concerns the gene TGFB1 and neoplasm.