Accordingly, after treatment with the Akt phosphorylation selective inhibitor MK‐2206 and the NF‐κB nuclear translocation inhibitor JSH‐23, LAMC1‐overexpressing ESCC cells showed the opposite results in proliferation and expression of cleaved caspase and PARP (Fig. 4D). The gene discussed is AKT1; the disease is esophageal squamous cell carcinoma.