We detected IKKα phosphorylation of Akt, IKKα and p65 levels in shLAMC1‐ and LAMC1‐overexpressing ESCC cells and found that LAMC1 expression was positively correlated with the phosphorylation of Akt, IKKα and p65 (Fig. 3B,C). The gene discussed is CHUK; the disease is esophageal squamous cell carcinoma.