To explore whether ESCC tumor cell‐secreted CXCL1, upregulated by LAMC1, influences CAF heterogeneity, we performed mRNA‐seq in the following cells: CAF treated with PBS; CAF with recombinant CXCL1 (rCXCL1) treatment; CAF with sh‐vec CM treatment. Here, CXCL1 is linked to esophageal squamous cell carcinoma.