Accordingly, after treatment with the Akt phosphorylation selective inhibitor MK‐2206 and the NF‐κB nuclear translocation inhibitor JSH‐23, LAMC1‐overexpressing ESCC cells showed the opposite results in proliferation and expression of cleaved caspase and PARP (Fig. 4D). Here, NFKB1 is linked to esophageal squamous cell carcinoma.