A multivariable COX regression analysis showed that in-hospital thrombotic events (HR: 2.481; 95% CI 1.336–4.609; p = 0.004), age (HR: 1.048; 95% CI 1.022–1.075; p < 0.001), baseline low albumin levels (HR: 0.447; 95% CI 0.277–0.723; p = 0.001) and low PaO2/FiO2 ratio (HR: 0.996; 95% CI0.993–0.999; p = 0.022) predicted mortality, after adjusting for sex, ICU admission, diabetes, CAD, heart failure and COPD. The gene discussed is ALB; the disease is chronic obstructive pulmonary disease.