For example, FTO promoted breast cancer progression by increasing the RNA degradation of the pro-apoptosis gene BNIP3 via m6A demethylation and a YTHDF2-independent mechanism [6] and promoted glioblastoma tumorigenesis and cancer stem cell self-renewal as a component of the m6A regulatory machinery [32]. The gene discussed is YTHDF2; the disease is breast carcinoma.