SFPQ has been identified as an essential melanoma gene in a CRISPR genome-wide loss of function screen [26], and analysis of this dataset revealed that melanoma cell lines (n = 46) show high dependency (DEMETER2 scores) on SFPQ regardless of its expression (i.e., poor correlation between dependency score and expression levels) (Fig. 1b). Here, SFPQ is linked to melanoma.