COL3A1 and neoplasm: Interestingly, gene-level analysis of SFPQ-enriched mRNA transcripts exclusively associated with PM revealed several targets that are frequently downregulated in melanoma and specifically associated with ECM architecture (COL1A2, COL3A1, Decorin, and Fubilin-1) (40), in addition to the proapoptotic tumour suppressor gene, DPP4, which has been reported as a suppressor of metastatic progression in melanoma [40].