ALCAM and Alzheimer disease: Another transcriptomic study [46] including an overlapping sample set of 2114 brain samples representing 478 cases and 300 controls identified significant evidence for differential gene expression in AD for both ALCAM (Z = 2.75, FDR = 2.76E-02) and BBX (Z = 3.73, FDR = 1.84E-03) (Additional file 9).