RAF1 and Noonan syndrome: Three (17.6%) patients (K1, K4, and K10) had suspected syndromes, such as Noonan syndrome, based on facial and clinical features, but no mutations were identified by Sanger sequencing of PTPN11, SOS1, RAF1, and KRAS. Patient K1 showed dysmorphic facial features, such as relative macrocephaly, broad nasal bridge, deep philtrum, hypertelorism, low set ears, strabismus, pectus excavatum, delayed teeth and closure (ossification) of the fontanelle, and GHD.