Univariate Cox regression analysis showed that age, etiology, hemoglobin level, serum albumin level, creatinine level, eGFR, proteinuria, urinary occult blood, UPCR, hypertension, diabetes, use of renin–angiotensin–aldosterone-system (RAAS) inhibitor, use of calcium channel blocker, and use of diuretics were correlated with CKD progression. This evidence concerns the gene REN and chronic kidney disease.