The association of TLR 4/TLR 9 and severity of malaria was reported in nine studies for TLR9 (T1237C) [20–27, 29], eight studies for TLR9 (T1486C) [20–24, 26, 27, 29], ten studies for TLR4 (D299G) [20–24, 26–30] and five studies for TLR4 (T399I) [20, 22, 23, 28, 29]. The gene discussed is TLR9; the disease is malaria.