In pathological conditions including cancer, not only lymphatic vessels but lymph nodes engage in disease progression and undergo remodeling in response to growth factors, chemokines and other signaling molecules secreted by tumor cells or other cells in pre-metastatic niches [62], including TGF-β, epidermal growth factor, vascular endothelial growth factor-C (VEGF-C) and CCR7 signaling and CCL1/CCR8. Here, VEGFC is linked to neoplasm.