PTPN11 and neoplasm: A gradient of 50,000, 5000 and 500 cells were inoculated into Balb/c-Nu nude mice, and the SHP2 overexpressing cells showed more aggressive tumor generation compared with SHP2 knock-down cells in both PC9 and PC9GR background (Fig. 4E), with an accelerated rate of tumorigenesis (Additional file 4: Table S1).