In the current study, we found a lower expression of let-7c in the alveolar macrophages with a remarkable reservation after 3-DZNeP treatment, which is concordant with recent studies showing that let-7c suppresses polarization of macrophages to the M1 phenotype and enhances M2 polarization in sepsis [23], while pharmacologic and genetic inhibition of EZH2 could lead to let-7c-mediated macrophage inflammatory phenotype reversion via PAK1-dependent NF-kB signaling pathway [23]. Here, EZH2 is linked to Sepsis.