We then evaluated the prognostic values of ARNTL2 in ccRCC, as plotted in Fig. 2a and b, elevated expression of ARNTL2 predicted poor OS in both TCGA (HR = 1.67, P = 0.001) and Kaplan–Meier plotter (HR = 1.91, P = 2.2e−05) database. This evidence concerns the gene BMAL2 and nonpapillary renal cell carcinoma.