High expression of ARNTL2 exhibited immune infiltration status similar to CD8 + inflamed ccRCC subtype, which was characterized by high infiltration level of CD8 + T cell and high expression of immune-escape genes such as PD1, PD-L1, PD-L2, and CTLA4. Here, PDCD1LG2 is linked to nonpapillary renal cell carcinoma.