Multivariate analysis, depicted as a forest boxplot in Fig. 2d, revealed that ARNTL2 expression (p = 0.01016), the age (p = 1e−05), pathological TNM stage (p < 0.0001), and tumor grade (p = 0.00083) were independent predictor of ccRCC patient OS. The gene discussed is BMAL2; the disease is neoplasm.