With the rise of the ARNTL2 expression, the immune score (P < 0.001), microenvironment score (P < 0.001) and stroma score (P < 0.05) in ccRCC TIME were enhanced (Fig. 7b), high expression level of ARNTL2 tightly linked to the infiltrating levels of CD8 + T cell, CD4 + memory T cell, Myeloid dendritic cell, macrophage and CD4 + Th2 T cell. This evidence concerns the gene CD8A and nonpapillary renal cell carcinoma.