Miao et al. reported that ccRCC patients with high PBRM1 mutation frequency could benefit more from immune checkpoint inhibitor (ICI) therapy compared with those with low mutation frequency [5], Braun et al. preformed a randomized clinical trial and reported that PBRM1 mutations can be used as a marker of ICI response in ccRCC [28]. This evidence concerns the gene PBRM1 and nonpapillary renal cell carcinoma.