The findings of the current study showed that ARNTL2 was significantly upregulated in ccRCC tissues and cell lines compared with normal kidney tissues and cell line, overexpression of ARNTL2 could predict unfavorable prognosis for ccRCC patients, a series of analysis and in vitro assays were further conducted to explore the oncogenic role of ARNTL2 and its associations with immune infiltration in ccRCC [10]. Here, BMAL2 is linked to nonpapillary renal cell carcinoma.