Univariate analysis indicated that ARNTL2 expression (HR = 1.45853, p = 0.00029), age (HR = 1.02888, p = 1e−05), pathological TNM stage (HR = 1.86653, p < 0.0001) and tumor grade (HR = 2.29073, p < 0.0001) were significantly correlated with OS of ccRCC (Fig. 2c). The gene discussed is BMAL2; the disease is nonpapillary renal cell carcinoma.