The results revealed that the renal cell carcinoma (NES = 1.96614, P-adjust < 0.001), focal adhesion (NES = 2.06698, P-adjust < 0.001), Toll-like receptor signaling pathway (NES = 1.965199, P-adjust < 0.001), JAK-STAT signaling pathway (NES = 1.999494, P-adjust < 0.001), T cell receptor signaling pathway (NES = 2.036177, P-adjust < 0.001) and cell cycle pathways (NES = 1.551655, P-adjust < 0.005) (Fig. 4a–f, Additional file 3: Table S3) were significantly enriched in upregulated ARNTL2 samples. Here, BMAL2 is linked to hereditary clear cell renal cell carcinoma.