A study showed that LRRK2 is amplified and overexpressed in papillary renal carcinoma, and down-regulation of LRRK2 in cultured tumor cells compromises cellular mesenchymal–epithelial transition factor (c-MET) signaling activation, which affects the growth and survival of tumor cells [15], but the expression of LRRK2 in clear cell renal cell carcinoma had not been studied. This evidence concerns the gene MET and neoplasm.