LRRK2 and neoplasm: With the cBioPortal, we conducted a more in-depth genomic analysis of 537 ccRCC patients for mutation sites of LRRK2 in tumor tissues (Fig. 3d) and found that LRRK2 tends to be slightly amplified (Fig. 3e), and confirmed that there is a negative correlation between LRRK2 expression and DNA methylation (Fig. 3f).