Subsequently, PubMed searches for these 10 key hub genes and ccRCC allow us to exclude 8 genes, namely VWF, FLT1, CCND1, PECAM1, SPARCL1, FZD1, CDH5, and INSR, as already known to be associated with ccRCC. This evidence concerns the gene CCND1 and nonpapillary renal cell carcinoma.