In differentiating early HCC from the healthy individuals, Egfl7 had a significantly higher sensitivity than AFP (75.9–77.4% vs. 58.9–65.3%%) and their accuracy and AUROC were similar indicating a generally superior of Egfl7 in the detection of early HCC to AFP as well as some other serum marker for early HCC, such as GPC3 (sensitivity ranged from 47.9 to 66.2%) [52] and DKK1 (sensitivity ranged from 70.9 to 73.8%) [24, 25]. This evidence concerns the gene DKK1 and hepatocellular carcinoma.