Out of the nine most commonly mutated genes in CH, accounting for the majority of CH contribution, the panel used in the present study only contained one, TP53. Contrary to previous reports, TP53 variants were not frequently detected in the control group in the present study (Hu et al. 2018; Fernandez-Cuesta et al. 2016). Here, TP53 is linked to cyclic hematopoiesis.