ACVRL1 and Bloom syndrome: At the transcriptome level, we found that many genes involved in wax biosynthesis were downregulated in BS, including the CYP94A1, HHT, HTH, CYP704C1, WSD1, and FAR3 genes and 10 KCS family genes, indicating that the decrease in wax may be one of the causes of BS(Fig. 3A B).