A statistically significant difference was observed in FABP-4 levels among the groups when compared the patients with acromegaly having DM and the controls, with acromegaly having DM and prediabetes, with acromegaly having DM and NGT, respectively (p = 0.014, p = 0.004, p = 0.001) (Figure). This evidence concerns the gene FABP4 and prediabetes syndrome.