RELN and Menkes disease: Over the years, novel genes causative of MD phenotypes have been reported, including the KCTD17 gene, with high expression in the putamen, which is likely to be involved in postsynaptic dopaminergic transmission [67]; CACNA1B gene, with N‐type calcium channel activity, is thought to be crucial in controlling neurotransmitter release [68]; RELN gene encodes reelin, an extracellular matrix glycoprotein which seems closely involved in modulation of synaptic function in adulthood [69].