T-bet+ Gata-3+ CD4+ T cells can occur in parasite infection (Hegazy et al., 2010), and T-bet/RORγt double-positive cells have been seen in murine experimental autoimmune encephalomyelitis models (Ghoreschi et al., 2010; Nistala et al., 2010). Here, GATA3 is linked to parasitic infectious disease.