Similarly, the deletion of cardiomyocytes SIRT3 induced brighter and injured mitochondria cristae, while significant damage was observed upon ischemia accompanied by the decreased surface area, perimeter, and aspect ratio, indicating the elongation of mitochondria caused by ischemia was blunted in cSIRT3−/− vs. SIRT3f/f hearts (Figure 4d). Here, SIRT3 is linked to ischemia.