DISC1 and major depressive disorder: Forebrain-specific neural progenitor cells and predominantly glutamatergic, but GABA-ergic and dopaminergic neuronal subtypes were also created using iPSCs of a patient with a frameshift DISC1 mutation and a diagnosed MDD (Wen et al., 2014) that showed dysregulated protein transcription and synaptic vesicle transport in neurons with the DISC1 mutation compared with control subjects.