In addition, Ifng and Il2 genes, whose liver expression was decreased by Lab4P (Figure 4), code for pro‐inflammatory cytokines IFN‐γ and IL‐2, respectively, that also impact VSMC function.[24] Both IFN‐γ and IL‐2 induce the release of MMPs, thereby promoting the degradation of the extracellular matrix (ECM)[24] and IFN‐γ also promotes apoptotic cell death of VSMC in atherosclerosis.[25]. The gene discussed is IFNG; the disease is atherosclerosis.