For endocrine-active adenomas, of 209 patients early biochemical remission was achieved in 148/209 (70.8%) patients: CD (55/81) 67.9%; GH (42/56) 75.0%, prolactinoma (46/66) 69.6%; TSH (3/3) 100%; GH-prolactin (1/2) 50%; GH-TSH (1/1) 100%. This evidence concerns the gene GH1 and adenoma.