This notion lends an additional support from (1) recent studies reporting that the mitochondrial fusion is required for the correct localization of the StAR protein and expression of its mRNA in MA-10 tumor Leydig cells after hormonal stimulation58,59 as well as (2) experimental studies showing importance of highly active (“energized”) mitochondria for proper functioning of Leydig cells in mice60. This evidence concerns the gene STAR and neoplasm.