Equally, in a previous study, the deletion of purinergic receptor 6 (P2Y6) from AgRP neurons caused changes in AgRP neuronal inputs to the liver44, suggesting that in our AgRP-GR KO mice, the improvement in insulin sensitivity could additionally be related to signalling to the liver, leading to the lower levels of hepatic steatosis. This evidence concerns the gene P2RY6 and fatty liver disease.