Equally, in a previous study, the deletion of purinergic receptor 6 (P2Y6) from AgRP neurons caused changes in AgRP neuronal inputs to the liver44, suggesting that in our AgRP-GR KO mice, the improvement in insulin sensitivity could additionally be related to signalling to the liver, leading to the lower levels of hepatic steatosis. The gene discussed is INS; the disease is Hepatic steatosis.