However, because the pleiotropic effects of TGF-β may have differential effects depending on concentration and in the present study our primary objective is to find treatments for persistent eye injuries where there is a need to activate mechanisms of regeneration including angiogenesis, stem cell activation and some degree of inflammation28, we believe, the higher concentrations of TGF-β found in CBED would be beneficial. This evidence concerns the gene TGFB1 and eye injury.