CASQ1 and thyroid gland disorder: As thyroid autoantibodies are known to play a role in pathogenesis and severity of TED14–16, other autoantibodies such as anti-calsequestrin 1 antibody (Anti-CASQ1 Ab) and anti-collagen XIII antibody (anti-COLXIII Ab) are also reported to be associated with the pathogenesis of TED17,18.