Phenotype–genotype correlation and co-segregation had been analyzed in candidate genes, including DSCAM, MAZ, KDM2B, VAV2, GLI2, GLI3, PLXNB2, LAMP2, and SHROOM3. Variants of LAMP2 were identified in the male twins who presented with proteinuria and hypertension during adolescence. The gene discussed is DSCAM; the disease is Hypertension.