The genetic causes of FSGS were shown including COQ8B (AR, 3), TRPC6 (AD, 2), PAX2 (AD,3), NPHS2 (AR,1), NUP160 (AR,1), WT1 (AD, 1) and UMOD (AD, 1). The gene discussed is PAX2; the disease is focal segmental glomerulosclerosis.