Phenotype–genotype correlation and co-segregation had been analyzed in candidate genes, including DSCAM, MAZ, KDM2B, VAV2, GLI2, GLI3, PLXNB2, LAMP2, and SHROOM3. Variants of LAMP2 were identified in the male twins who presented with proteinuria and hypertension during adolescence. This evidence concerns the gene KDM2B and hypertensive disorder.