The genetic causes of FSGS were shown including COQ8B (AR, 3), TRPC6 (AD, 2), PAX2 (AD,3), NPHS2 (AR,1), NUP160 (AR,1), WT1 (AD, 1) and UMOD (AD, 1). The gene discussed is UMOD; the disease is focal segmental glomerulosclerosis.