TNF and psoriasis: Consistent with the perturbed TNF/IL-12/IL-6 secretion, we found that Zc3h12c−/− mice had ~2-fold lower murine Psoriasis Severity Index (mPASI) score than Zc3h12c+/+ mice at days 3–4, the peak of IMQ-induced psoriatic lesions (Fig. 5a).