Notably, we found that genes implicated in EMT (e.g., SPARC and IGFBP2), formation of tumor cell-platelet microaggregates (e.g., GP1BA and VWF) and immunosuppressive chemokines (e.g., CCL5 and CXCL5) showed increased expression from HV to PA, and retained their elevated expression level in PV and PoV (Fig. 3e). The gene discussed is SPARC; the disease is neoplasm.