In patients with stable ischemic heart disease, higher GDF11/8 levels have been reported to be associated with a lower risk of cardiovascular events and death [11], while both endogenous and exogenous GDF11 have been demonstrated to protect the heart against IR injury in mice by enhancing the proliferation of cardiac progenitor cells [12] and attenuating noncanonical transforming growth factor-β (TGF-β) signaling, respectively. Here, GDF11 is linked to coronary artery disorder.