Since RANK/RANKL signalling and the TGF-β/pTHrP-mediated overexpression of RANKL have been reported to be closely associated with osteolytic BoM in NSCLC [6, 9, 10, 24, 25], we performed additional experiments to probe the effect of exosomal lncRNA-SOX2OT on the above-mentioned signalling pathways. This evidence concerns the gene TNFRSF11A and non-small cell lung carcinoma.