GRHL2 and non-small cell lung carcinoma: In our study, the expression of exosomal lncRNA-SOX2OT was abnormally increased in the peripheral blood of NSCLC patients with BoM, and the levels of lncRNA-SOX2OT in NSCLC patient-derived exosomes were inversely correlated with the overall survival of NSCLC patients, indicating that exosomal lncRNA-SOX2OT could potentially serve as a powerful prognostic biomarker.