Since lncRNA-SOX2OT was found to regulate miR-194-5p, RAC1 and TGF-β/pTHrP/RANKL signalling in vitro, we further examined the effects of exosomal lncRNA-SOX2OT on osteoclast-related proteins and pathways in the NSCLC BoM model. This evidence concerns the gene TGFB1 and non-small cell lung carcinoma.