Our data will show the clinical significance that exosomal lncRNA-SOX2OT may serve as a powerful prognostic biomarker for NSCLC patients with BoM and uncover a molecular mechanism by which NSCLC cell-derived exosomal lncRNA-SOX2OT modulates osteoclast differentiation and stimulates BoM by targeting the miRNA-194-5p/RAC1 signalling axis and TGF-β/pTHrP/RANKL signalling pathway in osteoclasts. This evidence concerns the gene PTHLH and non-small cell lung carcinoma.