The analysis of cytokine production by HLN cells from infected sheep showed that rFhCB3, rFhCB2 and rFhCL2 induced the highest level of IL-10 and IFN-γ secretion, whereas a lack of production was observed for IL-4, which suggests these peptidases might be able to drive Th1 (IFN-γ) and Th2 (IL-4, IL-10) responses during the early stage of the infection. This evidence concerns the gene LAP3 and infection.