Prdx1-knockout mice (Prdx1−/−) develop an age-related haemolytic anaemia, linked to higher levels of ROS in erythrocytes and various types of malignancies (lymphomas, sarcomas and carcinomas) associated with increased ROS-dependent DNA damage and functional c-Myc deregulation. This evidence concerns the gene PRDX1 and non-autoimmune hemolytic anemia.