In a recent individual participant data pooled-analysis of published studies on rectal cancer surgery, logistic regression models were estimated for the risk of local, systemic and overall recurrence, showing a higher local and overall recurrences for ypT3 stage, tumor size after radiotherapy > 10 mm and lack of combined chemotherapy, while ypT3 was the only factor correlated with systemic recurrence [166]. This evidence concerns the gene RAB11B and neoplasm.