Regardless of the contradictory reports, most agree that the response of the Akt/mTOR axis to neurotrophin/insulin stimulation is suppressed in AD, consistent with a state of insulin resistance, and that mTORC1 inhibition with rapamycin is neuroprotective, reduces proteinopathy and actually restores memory formation and maintenance [155, 192]. The gene discussed is MTOR; the disease is Alzheimer disease.