A polyclonal antibody, used to detect PSAP, SAP-A and SAP-B on the western blots but not distinguishing PSAP from SAP-A, SAP-B by immunohistochemical staining, labeled DNs that surrounded amyloid plaques in all three AD mouse models (Fig. 1A, top row, collectively as SAPs). This evidence concerns the gene SKAP2 and Alzheimer disease.