POGZ and white-sutton syndrome: White-Sutton (WHSUS, MIM #616364) is a recently recognized syndrome caused by mutations of the POGZ (pogo transposable element-derived protein with zinc finger domain) gene, encoding for a multidomain nuclear protein that regulates chromatin remodeling, chromosome segregation and mitotic progression, making the majority of cells to prematurely exit mitosis with consequent depletion of neurogenic progenitor cells [1, 2].