To investigate the biological role of PML-II in IFNα-induced cell death, we employed PML-II specific siRNA in HeLa cells, which are a cervical cancer cell line that has been shown to express PML-II and to be susceptible to IFNα-induced apoptosis [36, 37]; PML-II is a major PML isoform in these cells (Fig. 1A). The gene discussed is IFNA1; the disease is cervical cancer.