Cells from PML-deficient mice showed severe apoptotic defects including a strongly decreased sensitivity to IFN-induced and death receptor-mediated apoptosis [10], while growth inhibition by IFNα in myeloma cells correlated with the presence of PML [11]; IFNα-induced apoptosis in hepatocellular carcinoma also involved PML [12]. The gene discussed is PML; the disease is hepatocellular carcinoma.