To investigate whether the three-gene panel could provide an accurate prediction of OS in GC patients, the prognostic risk scores of the panel was formulated in the training dataset (GSE15459) and validating dataset (TCGA) based on the coefficient of the three genes in multivariate analysis: Risk score =  (0.180 × expression value of AGT) +  (0.544 × expression value of SERPINH1) +  (0.135 × expression value of MMP7). Here, MMP7 is linked to gastric cancer.