To elaborate on the potential vascular profile of the C32 and SK-Mel-28 melanoma cells, flow cytometric analysis was used to determine the expression of endothelial cell (EC) surface antigens VE-cadherin (CD144), PECAM (CD31), VEGFR2 (CD309), Tie-2 (CD202b) and MCAM (CD146). The gene discussed is MCAM; the disease is melanoma.