When complexed with G9a, EHMT1 is mainly responsible for monomethylation‐ and dimethylation‐related modifications of H3K9 in euchromatin regions [2, 3], and EHMT1 overexpression is associated with poor cancer‐specific survival in esophageal squamous cell cancer [25]. Here, EHMT2 is linked to esophageal squamous cell carcinoma.