PROM1 and glioblastoma: However, knockdown of PROM1/CD133 leads to the disruption of self‐renewal and tumorigenic abilities of neurosphere‐derived human glioblastoma cells, and the re‐expression of CD133 restores the stem cell‐like phenotype in PROM1/CD133‐silenced glioblastoma cells, suggesting that CD133 plays an important role in the maintenance of stem cell‐like properties of GICs [11].